Enhanced Tonic GABA Current in Normotopic and Hilar Ectopic Dentate Granule
نویسندگان
چکیده
1 Cells after Pilocarpine-Induced Status Epilepticus 2 3 Ren-Zhi Zhan and J. Victor Nadler 4 Department of Pharmacology and Cancer Biology and Department of Neurobiology, Duke 5 University Medical Center, Durham, North Carolina 27710 6 7 Running head: Tonic GABA Current of Granule Cells in Epilepsy 8 9 Correspondence: J. Victor Nadler, Department of Pharmacology and Cancer Biology, Box 3813, 10 Duke University Medical Center, Durham, NC 27710. Telephone: (919) 684-5317. FAX: (919) 11 681-8609. E-mail: [email protected]. 12 13 14 Articles in PresS. J Neurophysiol (May 27, 2009). doi:10.1152/jn.00147.2009
منابع مشابه
Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus.
In temporal lobe epilepsy, loss of inhibitory neurons and circuit changes in the dentate gyrus promote hyperexcitability. This hyperexcitability is compensated to the point that dentate granule cells exhibit normal or even subnormal excitability under some conditions. This study explored the possibility that compensation involves enhanced tonic GABA inhibition. Whole cell patch-clamp recordings...
متن کاملHigh ratio of synaptic excitation to synaptic inhibition in hilar ectopic granule cells of pilocarpine-treated rats.
After experimental status epilepticus, many dentate granule cells born into the postseizure environment migrate aberrantly into the dentate hilus. Hilar ectopic granule cells (HEGCs) have also been found in persons with epilepsy. These cells exhibit a high rate of spontaneous activity, which may enhance seizure propagation. Electron microscopic studies indicated that HEGCs receive more recurren...
متن کاملIntrinsic neurophysiological properties of hilar ectopic and normotopic dentate granule cells in human temporal lobe epilepsy and a rat model.
Hilar ectopic dentate granule cells (DGCs) are a salient feature of aberrant plasticity in human temporal lobe epilepsy (TLE) and most rodent models of the disease. Recent evidence from rodent TLE models suggests that hilar ectopic DGCs contribute to hyperexcitability within the epileptic hippocampal network. Here we investigate the intrinsic excitability of DGCs from humans with TLE and the ra...
متن کاملStatus epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells.
Temporal lobe epilepsy is associated with loss of interneurons and inhibitory dysfunction in the dentate gyrus. While status epilepticus (SE) leads to changes in granule cell inhibition, whether dentate basket cells critical for regulating granule cell feedforward and feedback inhibition express tonic GABA currents (I(GABA)) and undergo changes in inhibition after SE is not known. We find that ...
متن کاملStatus epilepticus enhances tonic GABA currents and depolarizes
*Authors contributed equally 8 Running title: Status epilepticus alters dentate basket cell tonic inhibition 9 Abstract 37 Temporal lobe epilepsy is associated with loss of interneurons and inhibitory dysfunction in the 38 dentate gyrus. While status epilepticus (SE) leads to changes in granule cell inhibition, whether 39 dentate basket cells critical for regulating granule cell feed-forward an...
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